A randomized, double‐blind, placebo‐controlled trial of levetiracetam for dyskinesia in Parkinson's disease
Identifieur interne : 000411 ( Main/Exploration ); précédent : 000410; suivant : 000412A randomized, double‐blind, placebo‐controlled trial of levetiracetam for dyskinesia in Parkinson's disease
Auteurs : Kitty K. Wong [Australie] ; Jane E. Alty [Australie] ; Amanda G. Goy [Australie] ; Sanjay Raghav [Australie] ; David C. Reutens [Australie] ; Peter A. Kempster [Australie]Source :
- Movement Disorders [ 0885-3185 ] ; 2011-07.
English descriptors
- KwdEn :
Abstract
Background:: This randomized double blind, placebo‐controlled crossover study investigated the antidyskinetic effects of levetiracetam in Parkinson's disease. Methods:: Sixteen participants with levodopa‐induced dyskinesia were enrolled. Hourly videotaped dyskinesia assessments scored by the Goetz method and hourly Unified Parkinson's Disease Rating Scale motor subscale scoring were conducted on 1 day at the end of each treatment period. Results:: Dyskinesia was slightly less on placebo (P = .26). Patient diary records also showed less dyskinesia on placebo (P = .10). Parkinsonism was a little worse on levetiracetam, at borderline statistical significance (P = .05). Conclusions:: Levetiracetam was well tolerated at doses up to 2000 mg per day, but we did not detect any antidyskinetic properties. © 2011 Movement Disorder Society
Url:
DOI: 10.1002/mds.23687
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">A randomized, double‐blind, placebo‐controlled trial of levetiracetam for dyskinesia in Parkinson's disease</title><author><name sortKey="Wong, Kitty K" sort="Wong, Kitty K" uniqKey="Wong K" first="Kitty K." last="Wong">Kitty K. Wong</name></author><author><name sortKey="Alty, Jane E" sort="Alty, Jane E" uniqKey="Alty J" first="Jane E." last="Alty">Jane E. Alty</name></author><author><name sortKey="Goy, Amanda G" sort="Goy, Amanda G" uniqKey="Goy A" first="Amanda G." last="Goy">Amanda G. Goy</name></author><author><name sortKey="Raghav, Sanjay" sort="Raghav, Sanjay" uniqKey="Raghav S" first="Sanjay" last="Raghav">Sanjay Raghav</name></author><author><name sortKey="Reutens, David C" sort="Reutens, David C" uniqKey="Reutens D" first="David C." last="Reutens">David C. Reutens</name></author><author><name sortKey="Kempster, Peter A" sort="Kempster, Peter A" uniqKey="Kempster P" first="Peter A." last="Kempster">Peter A. Kempster</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:8F45041232E77884EFF21964CFBEE2F0ACAB37C7</idno><date when="2011" year="2011">2011</date><idno type="doi">10.1002/mds.23687</idno><idno type="url">https://api.istex.fr/document/8F45041232E77884EFF21964CFBEE2F0ACAB37C7/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">002233</idno><idno type="wicri:Area/Main/Curation">001F19</idno><idno type="wicri:Area/Main/Exploration">000411</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">A randomized, double‐blind, placebo‐controlled trial of levetiracetam for dyskinesia in Parkinson's disease</title><author><name sortKey="Wong, Kitty K" sort="Wong, Kitty K" uniqKey="Wong K" first="Kitty K." last="Wong">Kitty K. Wong</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Neurosciences Department, Monash Medical Centre, Melbourne</wicri:regionArea><wicri:noRegion>Melbourne</wicri:noRegion></affiliation></author><author><name sortKey="Alty, Jane E" sort="Alty, Jane E" uniqKey="Alty J" first="Jane E." last="Alty">Jane E. Alty</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Neurosciences Department, Monash Medical Centre, Melbourne</wicri:regionArea><wicri:noRegion>Melbourne</wicri:noRegion></affiliation></author><author><name sortKey="Goy, Amanda G" sort="Goy, Amanda G" uniqKey="Goy A" first="Amanda G." last="Goy">Amanda G. Goy</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Neurosciences Department, Monash Medical Centre, Melbourne</wicri:regionArea><wicri:noRegion>Melbourne</wicri:noRegion></affiliation></author><author><name sortKey="Raghav, Sanjay" sort="Raghav, Sanjay" uniqKey="Raghav S" first="Sanjay" last="Raghav">Sanjay Raghav</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Neurosciences Department, Monash Medical Centre, Melbourne</wicri:regionArea><wicri:noRegion>Melbourne</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Medicine, Monash University, Melbourne</wicri:regionArea><wicri:noRegion>Melbourne</wicri:noRegion></affiliation></author><author><name sortKey="Reutens, David C" sort="Reutens, David C" uniqKey="Reutens D" first="David C." last="Reutens">David C. Reutens</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Neurosciences Department, Monash Medical Centre, Melbourne</wicri:regionArea><wicri:noRegion>Melbourne</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Medicine, Monash University, Melbourne</wicri:regionArea><wicri:noRegion>Melbourne</wicri:noRegion></affiliation></author><author><name sortKey="Kempster, Peter A" sort="Kempster, Peter A" uniqKey="Kempster P" first="Peter A." last="Kempster">Peter A. Kempster</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Neurosciences Department, Monash Medical Centre, Melbourne</wicri:regionArea><wicri:noRegion>Melbourne</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Medicine, Monash University, Melbourne</wicri:regionArea><wicri:noRegion>Melbourne</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-07">2011-07</date><biblScope unit="volume">26</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="1552">1552</biblScope><biblScope unit="page" to="1555">1555</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">8F45041232E77884EFF21964CFBEE2F0ACAB37C7</idno><idno type="DOI">10.1002/mds.23687</idno><idno type="ArticleID">MDS23687</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>dyskinesia</term><term>levetiracetam</term><term>levodopa</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background:: This randomized double blind, placebo‐controlled crossover study investigated the antidyskinetic effects of levetiracetam in Parkinson's disease. Methods:: Sixteen participants with levodopa‐induced dyskinesia were enrolled. Hourly videotaped dyskinesia assessments scored by the Goetz method and hourly Unified Parkinson's Disease Rating Scale motor subscale scoring were conducted on 1 day at the end of each treatment period. Results:: Dyskinesia was slightly less on placebo (P = .26). Patient diary records also showed less dyskinesia on placebo (P = .10). Parkinsonism was a little worse on levetiracetam, at borderline statistical significance (P = .05). Conclusions:: Levetiracetam was well tolerated at doses up to 2000 mg per day, but we did not detect any antidyskinetic properties. © 2011 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Australie</li></country></list><tree><country name="Australie"><noRegion><name sortKey="Wong, Kitty K" sort="Wong, Kitty K" uniqKey="Wong K" first="Kitty K." last="Wong">Kitty K. Wong</name></noRegion><name sortKey="Alty, Jane E" sort="Alty, Jane E" uniqKey="Alty J" first="Jane E." last="Alty">Jane E. Alty</name><name sortKey="Goy, Amanda G" sort="Goy, Amanda G" uniqKey="Goy A" first="Amanda G." last="Goy">Amanda G. Goy</name><name sortKey="Kempster, Peter A" sort="Kempster, Peter A" uniqKey="Kempster P" first="Peter A." last="Kempster">Peter A. Kempster</name><name sortKey="Kempster, Peter A" sort="Kempster, Peter A" uniqKey="Kempster P" first="Peter A." last="Kempster">Peter A. Kempster</name><name sortKey="Raghav, Sanjay" sort="Raghav, Sanjay" uniqKey="Raghav S" first="Sanjay" last="Raghav">Sanjay Raghav</name><name sortKey="Raghav, Sanjay" sort="Raghav, Sanjay" uniqKey="Raghav S" first="Sanjay" last="Raghav">Sanjay Raghav</name><name sortKey="Reutens, David C" sort="Reutens, David C" uniqKey="Reutens D" first="David C." last="Reutens">David C. Reutens</name><name sortKey="Reutens, David C" sort="Reutens, David C" uniqKey="Reutens D" first="David C." last="Reutens">David C. Reutens</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000411 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000411 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:8F45041232E77884EFF21964CFBEE2F0ACAB37C7
|texte= A randomized, double‐blind, placebo‐controlled trial of levetiracetam for dyskinesia in Parkinson's disease
}}
| This area was generated with Dilib version V0.6.23. |  |